Brisby Dome is a round, bee-hive like structure owned by Roy Brisby in Brisbyland. Roy Brisby intends to pattern "Brisby Life" after it to create an ideal society that is clean and self-sufficient.
In the Venture Bros episode The Incredible Mr. Brisby, Dr. Thaddeus "Rusty" Venture is captured offered a place within the Dome's society in return for making a clone of Roy. He rejects this and is taken for interrogation. However, an attack of Orange County Liberation Front throws the dome into chaos and allows The Venture Family to reunite and escape.